Margaret of Anjou (French: Marguerite d'Anjou) (23 March 1430 – 25 August 1482) was the wife of King Henry VI of England. As such, she was Queen consort of England from 1445 to 1461 and again from 1470 to 1471. She also claimed to be Queen consort of France from 1445 to 1453. Born in the Duchy of Lorraine, into the House of Valois-Anjou, Margaret was the second eldest daughter of René I of Naples and Isabella, Duchess of Lorraine.

She was one of the principal figures in the series of dynastic civil wars known as the Wars of the Roses and at times personally led the Lancastrian faction. Due to her husband's frequent bouts of insanity, Margaret ruled the kingdom in his place.