This new edition is the first to be released since orofacial pain was recognized as the 12th dental specialty by the American Dental Association. Although the structure resembles previous editions, significant changes have been made. The most recent International Classification of Diseases, Eleventh Edition (ICD-11) classification system is used throughout, featuring new diagnostic codes and tables mapping differences between ICD-10 and ICD-11. Other revisions are inclusion of cervical spinal disorders and associated headaches as well as extracranial and systemic causes of orofacial pain, greater emphasis on headache pathophysiology and updates to management including new pharmacologic agents, and sections on "newer trends" related to electronic cigarettes/vaping and the SARS-CoV-2 global pandemic. Out with the old, in with the new. This text delivers the evidence-based assessment, diagnosis, and management of orofacial pain conditions to keep you up to date about this emerging and expanding field.